As COVID-19 transitions from pandemic to endemic status, understanding current guidelines helps maintain protection while resuming normal activities. **Latest Prevention Strategies:** 1. **Vaccination Recommendations:** - Primary series for all eligible individuals - Updated boosters targeting current variants - Special schedules for immunocompromised - Consideration for travel/occupational risks 2. **Masking Guidance:** - High-quality masks (N95/KN95) in crowded indoor spaces - Local transmission rate considerations - Special protection for high-risk individuals - Healthcare settings may have specific requirements 3. **Testing Protocols:** - At-home rapid tests for symptomatic individuals - PCR confirmation when accuracy needed - Testing before high-risk gatherings - Workplace/school testing programs **Treatment Updates:** 1. **Antiviral Medications:** - Paxlovid (nirmatrelvir/ritonavir) - Molnupiravir (alternative when Paxlovid contraindicated) - Remdesivir (IV treatment) - Must start within 5 days of symptoms 2. **Monoclonal Antibodies:** - Variant-specific formulations - For high-risk outpatients - IV or subcutaneous administration 3. **Supportive Care:** - Rest and hydration - Fever/pain management - Oxygen monitoring (pulse oximeter) - Hospitalization for severe cases **Long COVID Management:** - Multidisciplinary clinics emerging - Cognitive rehabilitation for brain fog - Graded exercise for fatigue - Breathing exercises for lung symptoms - Mental health support **Special Populations:** - Older adults - Immunocompromised individuals - Pregnant women - Pediatric considerations - Those with chronic conditions **Current CDC Guidelines:** - Isolation for 5 days after positive test - Masking days 6-10 if symptoms improving - No quarantine for exposures (with precautions) - Return-to-work policies - School/daycare recommendations **Global Surveillance:** - Emerging variant monitoring - Wastewater testing programs - Hospitalization metrics - Vaccine effectiveness studies Stay informed through reliable sources like CDC, WHO, and local health departments as guidelines continue evolving with the virus.